Murine Thigh Infection
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چکیده
منابع مشابه
Visualization of Abscess Formation in a Murine Thigh Infection Model of Staphylococcus aureus by 19F-Magnetic Resonance Imaging (MRI)
BACKGROUND During the last years, (19)F-MRI and perfluorocarbon nanoemulsion (PFC) emerged as a powerful contrast agent based MRI methodology to track cells and to visualize inflammation. We applied this new modality to visualize deep tissue abscesses during acute and chronic phase of inflammation caused by Staphylococcus aureus infection. METHODOLOGY AND PRINCIPAL FINDINGS In this study, a m...
متن کاملComparative Pharmacodynamics of Telavancin and Vancomycin in the 1 Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus
1 Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus 2 aureus 3 Alexander J. Lepak, Miao Zhao, David R. Andes # 4 5 Department of Medicine, University of Wisconsin School of Medicine and Public Health, 6 Madison, WI, USA 7 Department of Medical Microbiology and Immunology, University of Wisconsin, 8 Madison, WI, USA 9 William S. Middleton Memorial VA Hospital, Madison, WI...
متن کاملCharacterizing in vivo pharmacodynamics of carbapenems against Acinetobacter baumannii in a murine thigh infection model to support breakpoint determinations.
Pharmacodynamic profiling data of carbapenems for Acinetobacter spp. are sparse. This study aimed to determine the pharmacodynamic targets of carbapenems for Acinetobacter baumannii based on a range of percentages of the dosing interval in which free drug concentrations remained above the MIC (fT>MIC) in the neutropenic murine thigh infection model. fT>MIC values of 23.7%, 32.8%, and 47.5% resu...
متن کاملfAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.
OBJECTIVES To elucidate the pharmacokinetic/pharmacodynamic (PK/PD) index that predicts colistin efficacy against Acinetobacter baumannii in neutropenic murine thigh and lung infection models, and to determine the extent of the emergence of resistance in vivo to colistin. METHODS PK/PD of colistin was studied in thigh and lung infection models against A. baumannii ATCC 19606 and two multidrug...
متن کاملPharmacodynamic assessment of ertapenem (MK-0826) against Streptococcus pneumoniae in a murine neutropenic thigh infection model.
The objective of this study was to determine the susceptibility breakpoint of a new carbapenem, ertapenem (MK-0826), against Streptococcus pneumoniae strains based on bacterial density and survival studies in a murine thigh infection model. Sixteen S. pneumoniae isolates for which MICs ranged from 0.015 to 4.0 mg/liter were tested with neutropenic ICR mice. Animals were infected with bacteria a...
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